Nutramedix<\/p>\n
Adrenal is a proprietary blend of the extracts of four adaptogenic plants \u2013 Panax quinquefolium, Astragalus mongholicus, Schisandra Chinensis, and Rhodiola Rosea. This proprietary blend supplies energy and replenishes depleted adrenal glands.\u00a0 The adrenal glands help the body respond to stress and also produce steroids that contribute to the production of over 100 hormones that are vital to optimum health. It is estimated that approximately 95% of the population of the United States suffers from some degree of Adrenal Fatigue which is any decrease in the ability of the adrenal glands to perform normal functions.<\/p>\n
ADAPTOGENIC<\/p>\n
ANTIOXIDANT<\/p>\n
ANTISPASMODIC<\/p>\n
ANTISEPTIC<\/p>\n
APHRODISIAC<\/p>\n
CARMINATIVE<\/p>\n
DEMULCENT<\/p>\n
DIAPHORETIC<\/p>\n
DIURETIC<\/p>\n
EXPECTORANT<\/p>\n
HYPOTENSIVE<\/p>\n
NERVINE<\/p>\n
STIMULANT<\/p>\n
STOMACHIC<\/p>\n
VASODILATOR<\/p>\n<\/div>\n<\/div>\n
An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Adrenal did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form.Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article<\/a><\/p>\n \u200d<\/p>\n<\/div>\n<\/div>\n Bystritsky, A., Kerwin, L., & Feusner, J. D. (2008). A pilot study of Rhodiola rosea (Rhodax\u00ae) for generalized anxiety disorder (GAD)<\/strong>. The Journal of Alternative and Complementary Medicine<\/em>, 14(2), 175-180. Full Article<\/a><\/p>\n Hu, D., Cao, Y., He, R., Han, N., Liu, Z., Miao, L., & Yin, J. (2012). Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates A\u03b2 1\u201342-induced memory impairment in mice<\/strong>. Oxidative Medicine and Cellular Longevity, 2012<\/em>. Full Article<\/a><\/p>\n Liu, Z., Li, X., Simoneau, A. R., Jafari, M., & Zi, X. (2012). Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy.<\/strong> Molecular Carcinogenesis<\/em>, 51(3), 257-267. Full Article<\/a><\/p>\n Qiu, Y. K., Dou, D. Q., Cai, L. P., Jiang, H. P., Kang, T. G., Yang, B. Y., … & Li, M. Z. (2009). Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells<\/strong>. Fitoterapia<\/em>, 80(4), 219-222. Full Article<\/a><\/p>\n Wang, C. Z., Aung, H. H., Zhang, B., Sun, S., Li, X. L., He, H., … & Yuan, C. S. (2008). Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells.<\/strong> Anticancer Research<\/em>, 28(5A), 2545-2551. Full Article<\/a><\/p>\n Mucalo, I., Jovanovski, E., Raheli\u0107, D., Bo\u017eikov, V., Romi\u0107, \u017d., & Vuksan, V. (2013). Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension<\/strong>. Journal of Ethnopharmacology<\/em>, 150(1), 148-153. Full Article<\/a><\/p>\n Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmstr\u00f6m, C., & Panossian, A. (2007). Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression<\/strong>. Nordic Journal of Psychiatry<\/em>, 61(5), 343-348. Full Article<\/a><\/p>\n Vuksan, V., Sievenpiper, J. L., Koo, V. Y., Francis, T., Beljan-Zdravkovic, U., Xu, Z., & Vidgen, E. (2000). American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus<\/strong>. Archives of Internal Medicine<\/em>, 160(7), 1009-1013. Full Article<\/a><\/p>\n Jeong, H. J., Ryu, Y. B., Park, S. J., Kim, J. H., Kwon, H. J., Kim, J. H., … & Lee, W. S. (2009). Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities<\/strong>. Bioorganic & Medicinal Chemistry<\/em>, 17(19), 6816-6823. Full Article<\/a><\/p>\n Giridharan, V. V., Thandavarayan, R. A., Sato, S., Ko, K. M., & Konishi, T. (2011). Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice.<\/strong> Free Radical Research<\/em>, 45(8), 950-958. Full Article<\/a><\/p>\n Scholey, A., Ossoukhova, A., Owen, L., Ibarra, A., Pipingas, A., He, K., … & Stough, C. (2010). Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study<\/strong>. Psychopharmacology<\/em>, 212(3), 345-356. Full Article<\/a><\/p>\n Tohda, C., Tamura, T., Matsuyama, S., & Komatsu, K. (2006). Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus.<\/strong> British Journal of Pharmacology<\/em>, 149(5), 532-541. Full Article<\/a><\/p>\n<\/div>\n<\/div>\n Cheng, N., Ren, N., Gao, H., Lei, X., Zheng, J., & Cao, W. (2013). Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice.<\/strong> Food and Chemical Toxicology<\/em>, 55, 234-240. Full Article<\/a><\/p>\n Battistelli, M., De Sanctis, R., De Bellis, R., Cucchiarini, L., Dach\u00e0, M., & Gobbi, P. (2009). Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour. <\/strong>European Journal of Histochemistry<\/em>, 49(3), 243-254. Full Article<\/a><\/p>\n Chen, C. F., Chiou, W. F., & Zhang, J. T. (2008). Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium.<\/strong> Acta Pharmacologica Sinica<\/em>, 29(9), 1103. Full Article<\/a><\/p>\n Kim, S. H., Hyun, S. H., & Choung, S. Y. (2006). Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. <\/strong>Biofactors<\/em>, 26(3), 209-219. Full Article<\/a><\/p>\n Yu, D., Duan, Y., Bao, Y., Wei, C., & An, L. (2005). Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate<\/strong>. Journal of Ethnopharmacology<\/em>, 98(1-2), 89-94. Full Article<\/a><\/p>\n De Sanctis, R., De Bellis, R., Scesa, C., Mancini, U., Cucchiarini, L., & Dach\u00e0, M. (2004). In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes.<\/strong> Biofactors<\/em>, 20(3), 147-159. Full Article<\/a><\/p>\n Kim, S. R., Lee, M. K., Koo, K. A., Kim, S. H., Sung, S. H., Lee, N. G., … & Kim, Y. C. (2004). Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate<\/strong>\u2010<\/strong>induced toxicity<\/strong>. Journal of Neuroscience Research<\/em>, 76(3), 397-405. Full Article<\/a><\/p>\n Ng, T. B., Liu, F., & Wang, H. X. (2004). The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis<\/strong>. Journal of Ethnopharmacology<\/em>, 93(2-3), 285-288. Full Article<\/a><\/p>\n Min, H. Y., Park, E. J., Hong, J. Y., Kang, Y. J., Kim, S. J., Chung, H. J., … & Kang, S. S. (2008). Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells<\/strong>. Bioorganic & Medicinal Chemistry Letters<\/em>, 18(2), 523-526. Full Article<\/a><\/p>\n Majewska, A., Gra\u017cyna, H., Miros\u0142awa, F., Natalia, U., Agnieszka, P., Alicja, Z., & Kura\u015b, M. (2006). Antiproliferative and antimitotic effect, S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells.<\/strong> Journal of Ethnopharmacology<\/em>, 103(1), 43-52. Full Article<\/a><\/p>\n Zhao, T., Mao, G., Mao, R., Zou, Y., Zheng, D., Feng, W., … & Chen, Y. (2013). Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.)<\/strong> Baill.<\/strong> Food and Chemical Toxicology<\/em>, 55, 609-616. Full Article<\/a><\/p>\n Qi, B., Liu, L., Zhang, H., Zhou, G. X., Wang, S., Duan, X. Z., … & Zhao, D. Q. (2014). Anti-fatigue effects of proteins isolated from Panax quinquefolium<\/strong>. Journal of Ethnopharmacology<\/em>, 153(2), 430-434. Full Article<\/a><\/p>\n Barton, D. L., Liu, H., Dakhil, S. R., Linquist, B., Sloan, J. A., Nichols, C. R., … & Loprinzi, C. L. (2013). Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. <\/strong>Journal of the National Cancer Institute<\/em>, 105(16), 1230-1238. Full Article<\/a><\/p>\n Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S. (2012). Rhodiola rosea for physical and mental fatigue: a systematic review.<\/strong> BMC Complementary and Alternative Medicine<\/em>, 12(1), 70. Full Article<\/a><\/p>\n Barton, D. L., Soori, G. S., Bauer, B. A., Sloan, J. A., Johnson, P. A., Figueras, C., … & Christensen, B. (2010). Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA<\/strong>. Supportive Care in Cancer<\/em>, 18(2), 179. Full Article<\/a><\/p>\n Shevtsov, V. A., Zholus, B. I., Shervarly, V. I., Vol’skij, V. B., Korovin, Y. P., Khristich, M. P., … & Wikman, G. (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. <\/strong>Phytomedicine<\/em>, 10(2-3), 95-105. Full Article<\/a><\/p>\n Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000). Rhodiola rosea in stress induced fatigue\u2014a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty<\/strong>. Phytomedicine<\/em>, 7(5), 365-371. Full Article<\/a><\/p>\n Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen<\/strong>.Phytomedicine<\/em>, 7(2), 85-89. Full Article<\/a><\/p>\n Yan, Q., Jiang, Z., Yang, S., Deng, W., & Han, L. (2005). A novel homodimeric lectin from Astragalus mongholicus with antifungal activity<\/strong>. Archives of Biochemistry and Biophysics<\/em>, 442(1), 72-81. Full Article<\/a><\/p>\n Oh, S. Y., Kim, Y. H., Bae, D. S., Um, B. H., Pan, C. H., Kim, C. Y., … & Lee, J. K. (2010). Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis<\/strong>. Bioscience, Biotechnology, and Biochemistry<\/em>, 74(2), 285-291. Full Article<\/a><\/p>\n Bawa, A. S., & Khanum, F. (2009). Anti<\/strong>\u2010<\/strong>inflammatory activity of Rhodiola rosea\u2013\u201ca second<\/strong>\u2010<\/strong>generation adaptogen\u201d<\/strong>. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives<\/em>, 23(8), 1099-1102. Full Article<\/a><\/p>\n Guo, L. Y., Hung, T. M., Bae, K. H., Shin, E. M., Zhou, H. Y., Hong, Y. N., … & Kim, Y. S. (2008). Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill<\/strong>. European Journal of Pharmacology<\/em>, 591(1-3), 293-299. Full Article<\/a><\/p>\n Jalsrai, A., Grecksch, G., & Becker, A. (2010). Evaluation of the effects of Astragalus mongholicus Bunge saponin extract on central nervous system functions<\/strong>. Journal of Ethnopharmacology<\/em>, 131(3), 544-549. Full Article<\/a><\/p>\n Wei, X. Y., Yang, J. Y., Wang, J. H., & Wu, C. F. (2007). Anxiolytic effect of saponins from Panax quinquefolium in mice<\/strong>. Journal of Ethnopharmacology<\/em>, 111(3), 613-618. Full Article<\/a><\/p>\n Perfumi, M., & Mattioli, L. (2007). Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice.<\/strong> Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives<\/em>, 21(1), 37-43. Full Article<\/a><\/p>\n Abidov, M., Crendal, F., Grachev, S., Seifulla, R., & Ziegenfuss, T. (2003). Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles.<\/strong> Bulletin of Experimental Biology and Medicine<\/em>, 136(6), 585-587. Full Article<\/a><\/p>\n Wang, M., Guilbert, L. J., Ling, L., Li, J., Wu, Y., Xu, S., … & Shan, J. J. (2001). Immunomodulating activity of CVT<\/strong>\u2010<\/strong>E002, a proprietary extract from North American ginseng (Panax quinquefolium)<\/strong>. Journal of Pharmacy and Pharmacology<\/em>, 53(11), 1515-1523. Full Article<\/a><\/p>\n Mattioli, L., Funari, C., & Perfumi, M. (2009). Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats<\/strong>. Journal of Psychopharmacology<\/em>, 23(2), 130-142. Full Article<\/a><\/p>\n Mattioli, L., & Perfumi, M. (2007). Rhodiola rosea L. extract reduces stress-and CRF-induced anorexia in rats.<\/strong>Journal of Psychopharmacology<\/em>, 21(7), 742-750. Full Article<\/a><\/p>\n Khanum, F., Bawa, A. S., & Singh, B. (2005). Rhodiola rosea: a versatile adaptogen. <\/strong>Comprehensive Reviews in Food Science and Food Safety<\/em>, 4(3), 55-62. Full Article<\/a><\/p>\n<\/div>\n<\/div>\n “I have Lyme disease and struggle with the chronic fatigue it causes. My adrenals and thyroid are just spent. This product was recommended by my doctor. It made a huge difference in my daily life.” -N.S.<\/p>\n \u201cImmensely helpful for someone like me with Chronic Lyme. I take 10 drops per day, which is less than the recommended dose.\u201d -J.M.<\/p>\n \u201cDoes the job! In fact, since using this, my morning cortisol has tested in the optimal zone for the first time in nearly a decade. Yay!!!\u201d \u2013 E.S<\/p>\n “Love this product. It has helped me immensely with Adrenal Fatigue. I take twice a day every day and I have much more energy than I had before.” -K.M.<\/p>\n “I found that this was helpful for me in my healing and use it regularly. If you have adrenal fatigue and are dealing with Lyme I recommend it.” -L.R.<\/p>\n<\/div>\n<\/div>\nMedical Conditions [peer-reviewed journals]<\/h2>\n
ANXIETY<\/strong><\/h4>\n
ALZHEIMER DISEASE <\/strong><\/h4>\n
BLADDER CANCER<\/strong><\/h4>\n
BREAST CANCER<\/strong><\/h4>\n
CARDIAC STIFFNESS<\/strong><\/h4>\n
DEPRESSION<\/strong><\/h4>\n
DIABETES<\/strong><\/h4>\n
INFLUENZA <\/strong><\/h4>\n
MEMORY LOSS<\/strong><\/h4>\n
Medicinal Properties [peer-reviewed journals]<\/h2>\n
ANTIOXIDANT<\/strong><\/h4>\n
ANTIPROLIFERATIVE<\/strong><\/h4>\n
ANTITUMOR <\/strong><\/h4>\n
ANTIFATIGUE <\/strong><\/h4>\n
ANTIFUNGAL<\/strong><\/h4>\n
ANTI-INFLAMMATORY <\/strong><\/h4>\n
ANTICONVULSIVE <\/strong><\/h4>\n
ANXIOLYTIC EFFECT<\/strong><\/h4>\n
ADAPTOGENIC EFFECT <\/strong><\/h4>\n
MITOCHONDRIAL SUPPORT<\/strong><\/h4>\n
IMMUNOMODULATING<\/strong><\/h4>\n
RELAXANT<\/strong><\/h4>\n
VARIOUS PROPERTIES<\/strong><\/h4>\n
Patient Reports<\/h2>\n
Dosage Information<\/h2>\n<\/div>\n